EXPLORING THE EFFECTS OF BYROPHYLLUM PINNATUM EXTRACT ON THE CEREBRUM OF ADULT WISTAR RATS
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Abstract
Herbal extracts which can serve as medicinal plants have been used since ancient times and
even considered the source of modern medicine. Bryphullum pinnatum extracts have been
shown to possess neuroprotective properties potentially useful in treating neurodegenerative
diseases. Bryophyllum pinnatum is a plant used to treat inflammations, infections, and also
have anti cancer properties. This study was carried out to explore the effects of Bryophyllum
pinnatum extract on the cerebrum of Adult Wistar rats.A total of thirty (30) rats weighing
between 140g-200g were randomly assigned into six (6) groups (A,B,C,D,E and F),with five
rats per group. Group A was control group while Group B,C,D,E and F were administered
with Bryophyllum pinnatum extract in doses of 200,400,600,800 and 1000mg/kg
respectively.The rats were acclimatized for a period of two weeks and administered for a
period of four weeks using oral route by the use of orogastric tube. The rats were
anesthesized with chloroform and then sacrificed. The cerebrum was harvested and
immediately fixed for antioxidant stress test and for tissue processing. H&E stains were used
for histological test. The result of the study shows that there was no statistically significant
difference (P<0.05) in the final body weight of rats in entire group compared to it's initial
body weigh except group B where there is a significant change in weight .There was no
statistically significant difference (P<0.05) in cerebrum weight and organo-somatic index. In
the chart showing the antioxidant results, it shows that it is not statistically significant. Histological slides in control group show: molecular, external granular, external pyramidal, internal granular, internal pyramidal and multi-form layers. Group B show: vasodilatation
normal pyramidal neurons with conspicuous nucleoles oligodendrocytes and neuropil. Group
C show: normal neurons with conspicuous nucleoles, oligodendrocytes, neuropril cerebral
vasodilatation. Group D show: normal granular cell neurons with conspicuous nucleoli, normal oligodendrocytes and marked vasodilatation and active congestion. Group E and F
marked show vasodilatation and active congestion, normal granular cells with conspicuous
nucleolus and oligodendrocytes. In conclusion, graded concentration of Bryophyllum
pinnatum induced vasogenic effects and increased protein synthesis in a dose dependent
fashion and it had no adverse effect on it.
even considered the source of modern medicine. Bryphullum pinnatum extracts have been
shown to possess neuroprotective properties potentially useful in treating neurodegenerative
diseases. Bryophyllum pinnatum is a plant used to treat inflammations, infections, and also
have anti cancer properties. This study was carried out to explore the effects of Bryophyllum
pinnatum extract on the cerebrum of Adult Wistar rats.A total of thirty (30) rats weighing
between 140g-200g were randomly assigned into six (6) groups (A,B,C,D,E and F),with five
rats per group. Group A was control group while Group B,C,D,E and F were administered
with Bryophyllum pinnatum extract in doses of 200,400,600,800 and 1000mg/kg
respectively.The rats were acclimatized for a period of two weeks and administered for a
period of four weeks using oral route by the use of orogastric tube. The rats were
anesthesized with chloroform and then sacrificed. The cerebrum was harvested and
immediately fixed for antioxidant stress test and for tissue processing. H&E stains were used
for histological test. The result of the study shows that there was no statistically significant
difference (P<0.05) in the final body weight of rats in entire group compared to it's initial
body weigh except group B where there is a significant change in weight .There was no
statistically significant difference (P<0.05) in cerebrum weight and organo-somatic index. In
the chart showing the antioxidant results, it shows that it is not statistically significant. Histological slides in control group show: molecular, external granular, external pyramidal, internal granular, internal pyramidal and multi-form layers. Group B show: vasodilatation
normal pyramidal neurons with conspicuous nucleoles oligodendrocytes and neuropil. Group
C show: normal neurons with conspicuous nucleoles, oligodendrocytes, neuropril cerebral
vasodilatation. Group D show: normal granular cell neurons with conspicuous nucleoli, normal oligodendrocytes and marked vasodilatation and active congestion. Group E and F
marked show vasodilatation and active congestion, normal granular cells with conspicuous
nucleolus and oligodendrocytes. In conclusion, graded concentration of Bryophyllum
pinnatum induced vasogenic effects and increased protein synthesis in a dose dependent
fashion and it had no adverse effect on it.
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