In vitro ANTIDIABETIC PROPERTIES OF THE AQUEOUS EXTRACT OF Sida acuta
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Abstract
Sida acuta commonly known as wire weed possesses several therapeutic properties that can be
recognized in traditional medicine. Sida acuta has been found to contain several photochemical
(flavonoids, tannins, steroids), antioxidant and antidiabetic properties. The aim of this study was
to determine the in vitro antidiabetic activities of the aqueous extract of Sida acuta on α- mylase
and α-glucosidase enzyme. In this study, the result on the α-amylase assay shows that the standard
(acarbose) has better in vitro antidiabetic properties on α-amylase enzyme by inhibiting α-amylase
at IC50 of 29997.9µg/ml when compared to the inhibitory properties of the aqueous Sida acuta
extract which had an IC50 of 42966.9µg/ml. The result obtained from the α-glucosidase assay
showed that the IC50 of the standard (acarbose) had better in vitro antidiabetic properties on the α-
glucosidase enzyme by inhibiting α-glucosidase at an IC50 of 10120.52µg/ml when compared to
that of the extract (IC50 of 14333.29µg/ml). In conclusion the extract displayed its medicinal
properties by inhibiting α-amylase and α-glucosidase enzyme and could be used as a possible anti
diabetic therapeutic agent.
recognized in traditional medicine. Sida acuta has been found to contain several photochemical
(flavonoids, tannins, steroids), antioxidant and antidiabetic properties. The aim of this study was
to determine the in vitro antidiabetic activities of the aqueous extract of Sida acuta on α- mylase
and α-glucosidase enzyme. In this study, the result on the α-amylase assay shows that the standard
(acarbose) has better in vitro antidiabetic properties on α-amylase enzyme by inhibiting α-amylase
at IC50 of 29997.9µg/ml when compared to the inhibitory properties of the aqueous Sida acuta
extract which had an IC50 of 42966.9µg/ml. The result obtained from the α-glucosidase assay
showed that the IC50 of the standard (acarbose) had better in vitro antidiabetic properties on the α-
glucosidase enzyme by inhibiting α-glucosidase at an IC50 of 10120.52µg/ml when compared to
that of the extract (IC50 of 14333.29µg/ml). In conclusion the extract displayed its medicinal
properties by inhibiting α-amylase and α-glucosidase enzyme and could be used as a possible anti
diabetic therapeutic agent.
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