MODIFICATIONS IN HAEMORHEOLOGICAL PARAMETERS IN SICKLE CELL ANAEMIA
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Abstract
Sickle Cell Disease (SCD) is a hereditary blood disorder characterized by the production of
abnormal haemoglobin (HbS), leading to the deformation of red blood cells (RBCs) into a sickle
shape. This study aims to investigate modifications in haemorheological parameters in sickle cell
anaemia. A comparative analysis was conducted involving 60 participants aged 16-40 years, categorized into three groups: sickle cell patients in crisis, sickle cell patients in steady state, and
non-sickle cell controls. Parameters such as osmotic fragility, ESR, fibrinogen concentration, and
red cell deformability were measured using standardized laboratory techniques. The study found
a significant increase in osmotic fragility among sickle cell subjects during crises compared to
steady state and controls (p < 0.05). Fibrinogen concentrations were markedly elevated in both
steady-state and crisis groups, with the highest levels observed during crises (p < 0.05). Similarly, ESR values were significantly higher in sickle cell subjects compared to controls (p < 0.05). However, no significant difference in red cell deformability was observed between sickle cell
and normal subjects (p > 0.05). The findings underscore the critical role of haemorheological
parameters in the pathophysiology of SCD, highlighting osmotic fragility, fibrinogen elevation, and ESR as important markers of disease activity and crisis severity
abnormal haemoglobin (HbS), leading to the deformation of red blood cells (RBCs) into a sickle
shape. This study aims to investigate modifications in haemorheological parameters in sickle cell
anaemia. A comparative analysis was conducted involving 60 participants aged 16-40 years, categorized into three groups: sickle cell patients in crisis, sickle cell patients in steady state, and
non-sickle cell controls. Parameters such as osmotic fragility, ESR, fibrinogen concentration, and
red cell deformability were measured using standardized laboratory techniques. The study found
a significant increase in osmotic fragility among sickle cell subjects during crises compared to
steady state and controls (p < 0.05). Fibrinogen concentrations were markedly elevated in both
steady-state and crisis groups, with the highest levels observed during crises (p < 0.05). Similarly, ESR values were significantly higher in sickle cell subjects compared to controls (p < 0.05). However, no significant difference in red cell deformability was observed between sickle cell
and normal subjects (p > 0.05). The findings underscore the critical role of haemorheological
parameters in the pathophysiology of SCD, highlighting osmotic fragility, fibrinogen elevation, and ESR as important markers of disease activity and crisis severity
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