LANDSCAPE

Protein folding is an important process that allows a long chain of amino acids (called a polypeptide) to form a specific three-dimensional shape needed for it to work properly. This project studies how proteins fold using the energy landscape model, which explains folding as a gradual movement toward the most stable and low-energy shape. By reviewing studies from 2020 to 2025 and comparing examples of amyloid-β, prion, and αsynuclein proteins, the research shows how changes in the folding process can cause proteins to fold incorrectly. When this happens, they may form clumps, leading to diseases such as Alzheimer’s and Parkinson’s. The findings show that protein folding is not random it is guided by chemical interactions, helper molecules called chaperones, and how easily different shapes can form. Misfolding occurs when proteins get stuck in the wrong shape, creating harmful structures. Overall, this study helps explain why protein folding is so important to human health. It also shows how understanding the energy landscape model can help scientists find better ways to prevent or treat diseases caused by misfolded proteins.