APOPTOTIC PROPERTIES

Acalypha wikesiana, a medicinal plant contains various phytochemicals which enable it perform its beneficial activities. It has gained attraction for its anti inflammatory and apoptotic properties. Colon cancer is a life threatening disease caused by several factors like genetics, environmental exposure and the damaging condition of the digestive tract. And as such 1, 2 dimethylhydrazine, an effective chemical substance was used to induce cancerous tumors in the colon and rectum. The aim of this study is to evaluate the anti inflammatory and apoptotic properties of Acalypha wikesiana on a DMH induced colon cancer. The sum of 46 healthy male rats were assembled into nine. The groups are a control group, a 1,2 dimethylhydrazine induced colon cancer group, which served as the standard drug group. The other groups were also induced with 1, 2 dimethylhydrazine but were treated with
different doses of Acalypha wikesiana extracts. The ninth group was the negative control group exposed only to 1,2 dimethylhydrazine. Results indicated significantly reduced tumor size and incidence. Reduced Proinflammatory markers level suggested an anti inflammatory effect of Acalypha wikesiana. In conclusion, it was indicated that Acalypha wikesiana ethanol extracts has an anti inflammatory and apoptotic properties which to a large extent contribute to its protective effects against 1,2 dimethylhydrazine induced colon cancer.