R. AIKPITANYI-IDUITUA

Watermelon (Citrullus lanatus) is Oxidative stress and inflammation are interconnected thatcontribute to a tropical fruit renowned for its hydrating qualities and rich nutritional content. It contains vital micronutrients such as vitamins A, B6, and C, as well as minerals and phytochemicals like lycopene and L-citrulline. These bioactive compounds possess significant antioxidant and anti-inflammatory properties that contribute to maintaining normal physiological function and protecting body systems from oxidative damage. Several studies have reported that natural fruit extracts, including watermelon juice, can enhance behavioral responses and regulate biochemical and hematological indices under oxidative or inflammatory stress conditions (Perkins-Veazie & Collins, 2021; Olayemi et al., 2020). physiological disturbances tissue injury, aging, and disease development. An imbalance between reactive oxygen species (ROS) production and the body’s antioxidant defenses can result in cellular damage affecting major organs, particularly the brain and circulatory system (Adebayo et al., 2019). Such pathological conditions often impair locomotor performance and alter blood and immune parameters. Therefore, evaluating the influence of watermelon juice—a naturally antioxidant-rich beverage—offers valuable insights into dietary interventions that may alleviate oxidative damage and preserve normal physiological functions.