D. O. Uwaya

Polyherbal teas, also known as herb-herb combinations, have been used in Chinese medicine practice, but scientific evidence of their therapeutic benefit is lacking. This study aims to examine the nutritional composition, characterization of some phytochemical constituents, and hepatoprotective activity of a poly-herbal tea formulation comprised of Moringa olifera, turmeric, ginger, garlic, and lemon in CCl4-induced hepatotoxicity. Proximate and mineral compositions were analyzed by the method described by the Association of Official Analytical Chemists (AOAC). The characterization of some phytochemical constituents was analyzed using HPLC. CCL4 induced hepatotoxicity was used for hepatoprotective activity. The proximate composition of poly-herbal formulated tea indicated carbohydrate (64.66 %), protein (19.25 %), fat (6.35 %), moisture content (6.12 %), ash content (0.24 %) and fibre (3.36%). Mineral compositions present include potassium (1356.0 mg/kg), calcium (821.3 mg/kg), magnesium (380.8 mg/kg), phosphorus (331.4 mg/kg), and iron (221.4 mg/kg).nt). Luteolin, Arbutin, Kaempferol, Apigenin and Quercetin were the most abundant phenolic compound, Quinine was the most abundant alkaloid, Diosgenin and Ergocalciferol were the most abundant steroid, Epigattotechin and Catechin were the most abundant tannins in polyherbal formulated tea. The body weight of animals given 10 mg/kg of the formulated tea extract, 5 mg/kg of the tea extract + CCL4, 10 mg/kg of tea extract + CCL4 and CCL4 without treatment significantly reduced compare to control (*p<0.05) in CCL4-induced nephrotoxicity. There was liver weight reduction in the animals that were given distilled water, 5 mg/kg of the formulated extract, 10mg/kg of the formulated extract, 5 mg/kg of the extract + CCL4, 10 mg/kg of extract + CCL4 when compared with CCL4 without treatment (***p<0.001; *p<0.05). ALP, AST and ALT levels in the animals were reduced by 5 mg/kg of the formulated tea extract, 10 mg/kg of the formulated extract, 5 mg/kg of the extract + CCL4, 10 mg/kg of extract + CCL4 when compared with CCL4 without treatment (**p<0.01; *p<0.05). Superoxide dismutase and catalase values were increased, and the molondialdehyde level was reduced by the formulated xv tea extract when compared with CCL4 without treatment (****p<0.0001; ***p<0.001; **p<0.01; *p<0.05). Conclusively polyherbal tea formulation (Moringa olifera, garlic, ginger, turmeric and lemon) possesses hepatoprotective activity

Medicinal plants have been essential to medicine for millennia, both modern and traditional. Nature's Gift® (Allium sativum, turmeric, ginseng, and bilberry) was tested for antidepressant and properties. The forced swim test, tail suspension test, and elevated plus maze were used to study antidepressants and anxiolytics. Twenty-five 20–30 gram mice were split into five groups of five. Group 1 received 10 ml/kg distilled water, Groups 2, 3, and 4 received 50, 100, and 200 mg/kg Nature Gift® extract, and Group 5 received 20 mg/kg oral fluoxetine. The mice were placed in an inescapable transparent cylinder filled with water at 25°C for one hour after receiving Nature's Gift® and fluoxetine. Animal immobility was recorded after 5 minutes of swimming. Twenty 20–30 gram mice were randomly assigned to five four-animal groups. Group 1 received distilled water (10 ml/kg), groups 2–4 Nature Gift extract (50, 100, and 200 mg/kg), and group 5 diazepam (10 mg/kg). An hour after receiving Nature's Gift® extracts and diazepam, the animals explored the central maze for five minutes. The number of entries and open arms time were recorded. Compared to the control, Nature's Gift® extract at 200 mg/kg and fluoxetine (20 mg/kg) reduced immobility time in the forced swimming test (p<0.05). Compared to the control, Nature's Gift® extract (50, 100, and 200 mg/kg) and fluoxetine (20 mg/kg) reduced tail suspension immobility time (p<0.05). Both Nature's Gift® extract (100 and 200 mg/kg) and diazepam (10 mg/kg) increased time spent in the open arm compared to the control (p<0.05). Nature's Gift® Supplement is an antidepressant and anxiolytic.