EFFECT OF AQUEOUS EXTRACT OF Musa paradisiaca ONTHE KIDNEY OF ADULT WISTARRATS
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Abstract
Musa paradisiaca (plantain) is widely used in traditional medicine and consumed as food, yet its renal safety profile remains poorly characterized. This study evaluated the dose dependent
effects of its aqueous extract on kidney function and oxidative stress in adult Wistar rats. Twenty-five rats were divided into five groups (A–E) and administered control, 100, 500, 750, and 1000 mg/kg of Musa paradisiaca extract orally for 16 days. Serumurea, creatinine, antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase(GPx)—and malondialdehyde (MDA) were assayed. Kidney weights, reno-somatic index(RSI), and histological features were evaluated. Serum urea increased significantly (p < 0.05) inratsreceiving 750 mg/kg and 1000 mg/kg extract compared with control. Antioxidant enzymeactivities (SOD, CAT, and GPx) declined notably at higher doses, whereas MDA levels hadnosignificantly, indicating absence of enhanced lipid peroxidation and oxidative stress. TheRSIwas elevated in the 1000 mg/kg group, although body weights were unaffected. Histological
sections showed preserved renal architecture across groups, suggesting functional rather than structural injury at higher doses. In conclusion the aqueous extract of Musa paradisiacaislargely safe at low to moderate doses but elicits biochemical signs of nephrotoxicity at higher concentrations. The findings justify the need for dosage regulation and caution in prolonged or high dose use of plantain based remedies
effects of its aqueous extract on kidney function and oxidative stress in adult Wistar rats. Twenty-five rats were divided into five groups (A–E) and administered control, 100, 500, 750, and 1000 mg/kg of Musa paradisiaca extract orally for 16 days. Serumurea, creatinine, antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase(GPx)—and malondialdehyde (MDA) were assayed. Kidney weights, reno-somatic index(RSI), and histological features were evaluated. Serum urea increased significantly (p < 0.05) inratsreceiving 750 mg/kg and 1000 mg/kg extract compared with control. Antioxidant enzymeactivities (SOD, CAT, and GPx) declined notably at higher doses, whereas MDA levels hadnosignificantly, indicating absence of enhanced lipid peroxidation and oxidative stress. TheRSIwas elevated in the 1000 mg/kg group, although body weights were unaffected. Histological
sections showed preserved renal architecture across groups, suggesting functional rather than structural injury at higher doses. In conclusion the aqueous extract of Musa paradisiacaislargely safe at low to moderate doses but elicits biochemical signs of nephrotoxicity at higher concentrations. The findings justify the need for dosage regulation and caution in prolonged or high dose use of plantain based remedies
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