SYNTHESIS OF 1-ETHYL-2-METHYL-4-NITROIMIDAZOLE- 5-THIOL
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Abstract
This research study aimed to produce 1-ethyl-2-methyl-4-nitroimidazole-5-thiol. Initially, N,N-diethyloxamide (Compound 1) was created through the reaction between diethyloxalate and ethylamine. Following this, 5-chloro-1-ethyl-2-methylimidazole
(Compound 2) was formed by treating N,N-diethyloxamide with phosphorus pentachloride. Compound 2 underwent nitration to produce 5-chloro-1-ethyl-2-methyl-4- nitroimidazole. The subsequent reaction of Compound 3 with thiourea resulted in the
formation of 1-ethyl-2-methyl-4-nitroimidazole-5-thiol. The purity of the compounds was assessed using thin-layer chromatography, recrystallization, and melting point determination methods.
(Compound 2) was formed by treating N,N-diethyloxamide with phosphorus pentachloride. Compound 2 underwent nitration to produce 5-chloro-1-ethyl-2-methyl-4- nitroimidazole. The subsequent reaction of Compound 3 with thiourea resulted in the
formation of 1-ethyl-2-methyl-4-nitroimidazole-5-thiol. The purity of the compounds was assessed using thin-layer chromatography, recrystallization, and melting point determination methods.
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