SWISS ALBINO MICE

SUBACUTE TOXICITY STUDY ON LIVER FUNCTION INDICES OF DICHLOROMEHTANE FRACTION OF Detarium microcarpium IN SWISS ALBINO MICE

Faculty
Department
Year of Publication
upload
Publication Type
Abstract
In tropical Africa, Detarium microcarpium serves as both vital industrial source and medicinal herb. An overview of D. microcarpium verified pharmacological qualities, including its effect on certain organ enzyme activity, acute and subacute toxicity, was the goal of this research. The leave of Detarium microcarpium are fit for several commercial and industrial uses, as was
discovered after a comprehensive literature review. Traditionally, D. microcarpium has been used to cure or alleviate the symptoms different illnesses and conditions in humans. In herbal therapy, this species is used to treat a wide range of conditions, from chest discomfort to cough to infertility to liver issues to menstrual pain to STDs. Antibacterial, antifungal, antihyperglycemic, antimalarial, antioxidant, and iron absorption are only some of the many pharmacological actions associated with D. microcarpium, as shown by pharmacological research. The fact that plants are natural does not guarantee their health benefit and safety. Some of these natural plants have been reported to cause renal and hepatic toxicity by deactivating and reducing the activity of both hepatic and renal enzymes. It is therefore expedient that these popularly known herbal medicines are widely studied with regards to their pharmacological and toxicological aspects in order to understand their safe doses and adverse effects. The chemical, nutritional, and toxicological qualities of Detarium microcarpium are interesting enough to warrant in-depth scientific examination. Animal experiments, randomized clinical trials, and subacute toxicity tests on specific organs are all necessary parts of a detailed research of Detarium microcarpium and its derivatives.
Supervisor(s)
co-supervisor