k. oriakhi

Aqueous extract of Gongronema latifolium was examined for its hepatoprotective properties. For a week, 98 male Wistar rats—which weigh between 120 and 150g each—were kept in orderly, quiet cages and given access to grower mash as needed to aid in their acclimatization. Groups of rats were separated out. The weight range of each group member was typical for the entire group. As a result, at the start of the experimental period, the rats had reached an average weight of 150–200g. Animals in Group 1 just got food and water as a standard control. In groups 2, 3, 4, and 5, diabetes was produced. Streptozotocin was used to stimulate the group 2 rats, however they were not given any medication. Streptozotocin was used to stimulate group 2 rats, but they were not given any further treatment, making them the negative control group. Metformin was used to initiate and treat the group 3 rats. Group 4 rats received 200mg/kg body weight of the bvaqueous fraction, and group 5 received 400mg/kg of the aqueous fraction. The results of the fasting blood glucose levels (mg/dl) of the rats in each group were: group 1, 84.40±2.50a, group 2, 348.10±10.20d, group 3, 108.50±6.20c, group 4, 160.20±1.25d, group 5, 150.12±2.50d, for each group respectively. The average body weights of the rats in each group were: group 1, 13.99±0.14, group 2, -21.44±0.11, group 3, 18.13±0.18, group 4, -13.72±0.11, group 5, 11.91±0.22. Gongronema latifolium significantly (p0.05) decreased fasting blood glucose level, raised albumin level, decreased ALT and AST level, and increased body weight in rats when administered at doses of 200 mg/kg body weight and 400 mg/kg aqueous fraction, respectively.