ANTIMICROBIAL ACTIVITIES

Heterocyclic compounds are very widely distributed in nature and very abundant in plant and animal products. They are included in many biochemical materials essential for life like nucleic acids (nucleotides), sugars and their derivatives, vitamin C and also, most members of vitamin B group (vitamin B6- pyridoxine). They are also found in application of diverse field such as agriculture, pharmaceutical and manufacturing industries. Researches have shown that heterocyclic nuclei give high chemotherapeutic values such as anti-malaria, anti-diabetics, anticancer and also act as a remedy for the development of novel drugs. Imidazole containing moiety occupied a unique position in organic compounds. It is a five-membered nitrogenous heterocyclic moiety that has three carbons, two nitrogens, four hydrogen atoms, and two double bonds having general molecular formula of C3H4N2. It is also known as 1,3-diazole because of the nitrogen atoms present at the first and third positions (non–adjacent position) of the ring, one nitrogen bear a hydrogen atom as the pyridine structure, and the other is called pyrrole type nitrogen
and position four and five are equivalent. It formed the basis of many therapeutic natural products such as histamine, purine, histidine among others