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Abstract
Inflammation is a protective biological response; however, when uncontrolled it contributes to the development of chronic diseases. Conventional anti-inflammatory drugs such as Ibuprofen, Aspirin, and other nonsteroidal anti-inflammatory drugs are effective but often associated with adverse effects during prolonged use. This study evaluated the synergistic anti-inflammatory activity of juices from Pineapple and Watermelon as a potential safer alternative for managing inflammation.
Fresh juices were prepared and administered to albino mice at doses of 10 and 20 ml/kg following acute toxicity testing. Anti-inflammatory activity was assessed using formalin-induced paw oedema, egg albumin-induced oedema, and Carrageenan-Induced Paw Edema models. The combination of pineapple and watermelon juice significantly reduced inflammation in a dose-dependent manner across all experimental models. In some instances, the anti-inflammatory effects were comparable to those produced by standard drugs such as ibuprofen and aspirin. No signs of severe toxicity or mortality were observed during the experiment.
The observed anti-inflammatory activity is attributed to the combined effects of bioactive compounds such as Bromelain, Lycopene, and L-Citrulline, which are known to regulate oxidative stress and inflammatory mediators. The findings suggest that pineapple and watermelon juice may serve as a safe, affordable, and natural functional food-based intervention for managing inflammatory conditions.
Fresh juices were prepared and administered to albino mice at doses of 10 and 20 ml/kg following acute toxicity testing. Anti-inflammatory activity was assessed using formalin-induced paw oedema, egg albumin-induced oedema, and Carrageenan-Induced Paw Edema models. The combination of pineapple and watermelon juice significantly reduced inflammation in a dose-dependent manner across all experimental models. In some instances, the anti-inflammatory effects were comparable to those produced by standard drugs such as ibuprofen and aspirin. No signs of severe toxicity or mortality were observed during the experiment.
The observed anti-inflammatory activity is attributed to the combined effects of bioactive compounds such as Bromelain, Lycopene, and L-Citrulline, which are known to regulate oxidative stress and inflammatory mediators. The findings suggest that pineapple and watermelon juice may serve as a safe, affordable, and natural functional food-based intervention for managing inflammatory conditions.
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