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Abstract
Traditional medicine due to its antimicrobial and therapeutic qualities against various diseases such as ethno-veterinary, fever, rheumatism, headache, colic, dyspepsia, uterine disorders, and pneumonia. The objective of this study is to investigate the phytochemical constituents of the leaves of Ageratum conyzoides and determine the antimicrobial activity of Ageratum conyzoides, so as to justify its usage in Traditional Medicine Practice. The fresh plants were collected, washed, cut into small pieces, air dried and pulverized to powder using mechanical grinder. Extraction was done by cold maceration.The methanol
extract and aqueous extracts of the plant portion were subjected to phytochemical analysis using the standard method. The Aqueous and Methanol extracts of the ageratum conyzoides plant were tested for their antimicrobial activity using the cup plate method against
Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Klebsiella pneumonia. The phytochemical investigation of the crude leaves extract of Ageratum conyzoides detected
the presence of bio-active substances like alkaloids, flavonoid, tannin, saponin, glycosides, and phenolics and carbohydrate. The Methanol extracts had a higher level of antibacterial activity against Staphylococcus
aureus, with the zone diameter of inhibition measuring 14 mm and 18mm for Escherichia coli. The aqueous water extract's zones of inhibition against E. coli was 9.5mm and 13mm of Staphylococcus aureus. The zones of inhibition of both the aqueous and methanol extracts were compared to that of an Analytical grade Ciprofloxacin antibiotics. The result of this investigation suggests that Ageratum conyzoides methanol extracts may be useful in treating illnesses and infections caused by S. aureus, and E. coli. which may be due to the presence of the its chemical constituent such as alkaloids, flavonoid, tannin, saponin, glycosides and phenol, thus justifying its use by traditional medicine practitioners
extract and aqueous extracts of the plant portion were subjected to phytochemical analysis using the standard method. The Aqueous and Methanol extracts of the ageratum conyzoides plant were tested for their antimicrobial activity using the cup plate method against
Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Klebsiella pneumonia. The phytochemical investigation of the crude leaves extract of Ageratum conyzoides detected
the presence of bio-active substances like alkaloids, flavonoid, tannin, saponin, glycosides, and phenolics and carbohydrate. The Methanol extracts had a higher level of antibacterial activity against Staphylococcus
aureus, with the zone diameter of inhibition measuring 14 mm and 18mm for Escherichia coli. The aqueous water extract's zones of inhibition against E. coli was 9.5mm and 13mm of Staphylococcus aureus. The zones of inhibition of both the aqueous and methanol extracts were compared to that of an Analytical grade Ciprofloxacin antibiotics. The result of this investigation suggests that Ageratum conyzoides methanol extracts may be useful in treating illnesses and infections caused by S. aureus, and E. coli. which may be due to the presence of the its chemical constituent such as alkaloids, flavonoid, tannin, saponin, glycosides and phenol, thus justifying its use by traditional medicine practitioners
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