OROBOR SUCCESS UWA

High blood pressure is a mounting worldwide health crisis, and a diet consistently high in salt is a major contributor. Whereas, widespread use of silver nanoparticles (AgNPs) leads to bioaccumulation, with studies confirming their tendencies to induce toxicological effects in these same organs. The aim of this study was to compare the effects of some of the antihypertensive drugs, Amlodipine, Lisinopril, Ascorbic Acid, and Losartan, alongside Nanosilver on both the kidney and the brain function in rats fed a long-term high-salt diet. Sixty-four (64) male Sprague dawley rats where divided into 8 groups (8 rats per group). Group 1(control) was given normal rats chow and water, Group 2 received high salt diet containing 8% NaCl, Group 3 received Nano-sliver and normal feed, Group 4 received high salt diets and Nanosilver, Group 5, received Nanos liver and Amlodipine (1mg/kg body weight), Group 6 received high salt diet and Lisinopril (2.3mg/kg body weight/ day). Group 7 received high salt diet and Vitamin C (50mg/kg bw/ day). Group 8 received high salt diet and Losartan (10mg/kg bw/day) for 12 weeks. All the animals were allowed access to water ad libitum and drugs administered by oral gavage. The Neurobehavioral functions and cognitions were assessed using Open field apparatus for Novel object recognition test (NOR), Y-maze for spontaneous movement and elevated plus maze for anxiety levels. Statistical analysis was done using T- test Graph Pad Prism Version 10.2.2, with significance set at (P<0.05). At the end of the study, blood samples were collected for biochemical analysis for urea, creatinine, sodium, potassium and nitrogen ion. The results of the study demonstrated that while chronic high salt intake did not promote a significant long-term weight gain, it did not produce detectable in blood serum urea, creatinine, potassium and nitrogen ion. In conclusion, the present study showed no indication of dysfunction in the blood parameters examined. This gives confidence in the blood and renal safety profile.