ONOSE PAMELA MOMODU

This research project investigates the phytochemical profile of methanol extract of Tetrapleura tetraptera fruit and its effect on the spleno- and hepato-somatic indices in cancer-induced Wistar rats. Dried fruit pods of Tetrapleura tetraptera were extracted using methanol via Soxhlet extraction, and preliminary phytochemical screening was conducted to identify major bioactive compounds. A portion of the concentrated crude extract was subjected to a detailed phytochemical screening, which identified bioactive constituents such as flavonoids, alkaloids, saponins, tannins, and glycosides, indicating the plant’s rich chemical composition. GC-MS analysis further revealed major compounds including nonadecane, octacosane, and squalene. The spleno- and hepato-somatic indices were calculated by analyzing spleen and liver weight relative to the total body weight after induction with phenyl hydrazine and treatment with the extract. The results show that the extract did not ameliorate phenyl hydrazine-induced splenomegaly. However, it exhibited a significant, dose-dependent hepatoprotective effect, preventing liver weight loss. The study highlights the Tetrapleura tetraptera fruit extract contains diverse phytochemicals and demonstrate a protective influence on liver morphology in Wistar rats