KENNEDY DAVID ONYEMACHI

Bryophyllum Pinnatum is an indigenous and exotic plant used widely by the traditional Practitioner for treating various ailment like renal calculi, hypertension, asthma, cold abscesses, bleeding disorder. This study was aimed to examine the protective effect of aqueous bryophyllum Pinnatum on Cadmium-induced renal oxidative damages. The kidney which is an integral part of the drug excretory system. It was reported as one of the targets of Cadmium toxicity in the cell include a decrease in cell membrane fluidity. Thirty male adult Wistar rats weighing 150g and 180g were divided into six groups [A,B,C,D,E,F] where group A [serves as Control] receives animal feed [grower mash] with distilled water for 28 days group B [ serves as toxicant] was given 10mg/kg of Cadmium chloride only for 28 days. Group c: receives 200mg/kg of bryophyllum pinnatum daily for 28 days. Group D: receoives 400mg/kg of bryophyllum pinnatum daily for 28 days. Group E: receives 200mg/kg of bryophyllum pinnatum and 10mg/kg of Cadmium chloride daily for 28 days. Group f: receive 400mg/kg of bryophyllum pinnatum and 10mg/kg of cadmium chloride daily for 28 days. Cadmium chloride and bryophyllum pinnatum extract was administered pro-gastric tube [oral gauge]. Biochemical analysis: renal function test was done and the following electrolytes was assayed. Urea test was done, creatinine test was done. The aqueous extract of bryophyllum