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Abstract
An Experimental Study in Adult Wistar Rats Metal poisoning and its impact on human health have increased due to industrialization and anthropogenic activities. This study aims to investigate the effect of glycine on cadmium-induced gastric damage in adult Wistar rats. Thirty rats were divided into six groups, including control, cadmium only, glycine only, and combinations of cadmium and glycine. Various biochemical markers were assessed, including oxidative stress indicators (SOD, MDA, CAT) and total protein. Histological analyses were performed on stomach tissues. Cadmium administration led to reduced body weight and increased malondialdehyde (MDA) levels, indicating oxidative damage. Superoxide dismutase (SOD) activity decreased, revealing compromised antioxidant defenses. However, catalase activity was largely unaffected by cadmium. Interestingly, glycine administration showed positive effects. It attenuated cadmium-induced MDA increase, maintained glutathione levels, and improved SOD activity. It also increased total protein levels. Histological observations demonstrated that cadmium induced inflammatory responses, muscle degeneration, and congestion in the stomach. Glycine treatment mitigated these effects, leading to near-normal tissue architecture. This study demonstrates that cadmium exposure can lead to oxidative stress and cellular damage, while glycine supplementation can exert a gastro-ameliorative effect by enhancing antioxidant defenses, maintaining glutathione levels, and mitigating histological alterations. These findings offer insight into the potential therapeutic benefits of glycine against cadmium-induced gastric damage. Glycine's availability and safety make it a promising avenue for further research and development of affordable gastro-ameliorative interventions
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