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This study evaluated the effects of Yoyo cleanser bitters on male Wistar rats fed with a high fructose diet. Yoyo Cleanser Bitters, a traditional herbal preparation, is purported to possess potential therapeutic properties for metabolic disorders. Twenty (20) male Wistar rats weighing
an average of 220grams each were randomly divided in four groups of five. The rats were fed ad-libitum with the feed and clean tap water during the entire course of the experiment (56 days). A basal diet of a standard pelleted grower’s marsh was given to the control group (group1), while the treatment diet of 60% high fructose diet along with 20% fructose water was fed to the other three cages. Atorvastatin (0.57mg/kg) was administered daily to group 3 and Yoyo cleanser bitters (1200 mg/kg) was administered to the rats in group 4. The treatment were administered using an oro-gastric gavage. Using standard methods, the weekly weight of the rats, their daily food consumption, feed efficiency were determined at the end of the 56days of study. Comprehensive biochemical assessment of lipid profile was performed. The data was analyzed using the one-way analysis of variance (ANOVA), followed by Tukey’s test of significance. A p value of less than 0.05 (p<0.05) was accepted as statistically significant (p<0.05). The results of the study revealed that High Yoyo cleanser bitters posses preventive properties related to metabolic disorders in male Wistar rats when compared with both control and Atorvastatin groups as it significantly reduced (p<0.05) the levels of Triglycerides, Low density lipoprotein, Very Low-density Lipoprotein levels yet increasing the high density lipoprotein levels. This is an indication that the mechanism of action of Yoyo Cleanser Bitters can be added as a preventive intervention for individuals at the risk of dyslipidemia
an average of 220grams each were randomly divided in four groups of five. The rats were fed ad-libitum with the feed and clean tap water during the entire course of the experiment (56 days). A basal diet of a standard pelleted grower’s marsh was given to the control group (group1), while the treatment diet of 60% high fructose diet along with 20% fructose water was fed to the other three cages. Atorvastatin (0.57mg/kg) was administered daily to group 3 and Yoyo cleanser bitters (1200 mg/kg) was administered to the rats in group 4. The treatment were administered using an oro-gastric gavage. Using standard methods, the weekly weight of the rats, their daily food consumption, feed efficiency were determined at the end of the 56days of study. Comprehensive biochemical assessment of lipid profile was performed. The data was analyzed using the one-way analysis of variance (ANOVA), followed by Tukey’s test of significance. A p value of less than 0.05 (p<0.05) was accepted as statistically significant (p<0.05). The results of the study revealed that High Yoyo cleanser bitters posses preventive properties related to metabolic disorders in male Wistar rats when compared with both control and Atorvastatin groups as it significantly reduced (p<0.05) the levels of Triglycerides, Low density lipoprotein, Very Low-density Lipoprotein levels yet increasing the high density lipoprotein levels. This is an indication that the mechanism of action of Yoyo Cleanser Bitters can be added as a preventive intervention for individuals at the risk of dyslipidemia
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