Favour Eseohe EROMOSELE

This study investigated the effects of Acanthus montanus leaf extract on kidney function in an experimental animal model. The research also aimed to scientifically validate the ethnomedicinal use of the plant in managing renal disorders. Fresh leaves of Acanthus montanus were collected, authenticated, air-dried, and extracted using distilled water. The animals (Male Wistar rats) were divided into control and treatment groups, respectively. The extract was administered at graded doses, and serum biochemical parameters, including Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), bilirubin, urea, and creatinine, were measured. Results indicated significant (p<0.05) dose-dependent reductions in elevated serum enzyme levels and improved renal function markers among treated groups compared to the control. The study provides scientific support for the traditional use of Acanthus montanus in managing kidney disorders. The results highlight its potential as a natural source of therapeutic agents for oxidative stress-related organ damage.