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Department
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Abstract
Antacids are usually alkaline substances that are used
to neutralize excess acid in the stomach and they are common over
the counter (OTC) medications used by patients to obtain fast
symptomatic relief from dyspepsia, heartburn, peptic ulcer, etc.
Some antacid products may neutralize more acid in the stomach than
others, the ability of an antacid to neutralize acid is expressed
as its acid neutralizing capacity (ANC). High technology equipment
like standard pH meter which is needed in the determination of
acid neutralizing capacity (ANC) are not readily available in
developing countries like Nigeria and there is also the issue of
epileptic power supply which makes it essential to determine a
suitable indicator that can be used in titrimetric method of
determining ANC which is inexpensive, simple and could be used in
routine monitoring of the quality of antacid suspensions.Also,the
Buffering capacity of the antacids are investigated to understand
the duration of action of their acid neutralizing action
Method: The United States Pharmacopeia (USP) method of analysis of
antacids was adopted,using acid-base titration (back/indirect
titration), the use of an indicator (Bromophenol Blue) was used to
determine the pH change in place of a pH meter. The samples were
coded A-T to avoid any bias in the study. All the sampled brands
has at least 1 year to expiry as indicated on the label.
xiv
Results: A pH greater than 3.5 was recorded for all the antacid
brands analyzed in the preliminary antacid test (PAT), this proved
that they are all antacids. All the brands of antacids analyzed
for their ANC were found to meet the specification of 5mEq/dose.
However, a wide variation in the ANC results was observed among
the brands where sample I was found to have the highest ANC value
(25.50mEq/dose), while sample A has the lowest ANC value
(8.50mEq/dose). Sample B has the highest buffering capacity which
was maintained for 25minutes while sample A and G also has the
lowest buffering capacity of just 5minutes.
Conclusion: The titrimetric procedure used in this study is simple,
inexpensive, and easy to use and could be used in routine
monitoring or periodic evaluation of the quality of Antacid
suspensions and this could help prescribers to make informed
choices for their patients.
x
to neutralize excess acid in the stomach and they are common over
the counter (OTC) medications used by patients to obtain fast
symptomatic relief from dyspepsia, heartburn, peptic ulcer, etc.
Some antacid products may neutralize more acid in the stomach than
others, the ability of an antacid to neutralize acid is expressed
as its acid neutralizing capacity (ANC). High technology equipment
like standard pH meter which is needed in the determination of
acid neutralizing capacity (ANC) are not readily available in
developing countries like Nigeria and there is also the issue of
epileptic power supply which makes it essential to determine a
suitable indicator that can be used in titrimetric method of
determining ANC which is inexpensive, simple and could be used in
routine monitoring of the quality of antacid suspensions.Also,the
Buffering capacity of the antacids are investigated to understand
the duration of action of their acid neutralizing action
Method: The United States Pharmacopeia (USP) method of analysis of
antacids was adopted,using acid-base titration (back/indirect
titration), the use of an indicator (Bromophenol Blue) was used to
determine the pH change in place of a pH meter. The samples were
coded A-T to avoid any bias in the study. All the sampled brands
has at least 1 year to expiry as indicated on the label.
xiv
Results: A pH greater than 3.5 was recorded for all the antacid
brands analyzed in the preliminary antacid test (PAT), this proved
that they are all antacids. All the brands of antacids analyzed
for their ANC were found to meet the specification of 5mEq/dose.
However, a wide variation in the ANC results was observed among
the brands where sample I was found to have the highest ANC value
(25.50mEq/dose), while sample A has the lowest ANC value
(8.50mEq/dose). Sample B has the highest buffering capacity which
was maintained for 25minutes while sample A and G also has the
lowest buffering capacity of just 5minutes.
Conclusion: The titrimetric procedure used in this study is simple,
inexpensive, and easy to use and could be used in routine
monitoring or periodic evaluation of the quality of Antacid
suspensions and this could help prescribers to make informed
choices for their patients.
x
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