ENVIRONMENTALMANAGEMENTANDTOXICOLOGY

In the realm of nanotechnology, the utilization of nanoparticles has surged across diverse industries, ranging from electronics to medicine. Among these nanoparticles, aluminum oxide nanoparticles (Al2O3– NPs) have gained significant attention due to their unique physicochemical properties. However, concerns regarding their potential toxicity have prompted extensive research into identifying strategies to mitigate their adverse effects. This study aimed to i vestigate the effects of Al2O3 nanoparticles on testis and epididymis of male wistar rat. The effects were investigated using hormonal assay, and standard methods to determine oxidative stress markers. In the current investigation, male wistar rats were given intraperitoneal doses of (Al2O3) 30 mg/kg, 50 mg/kg, 70 mg/kg, 100 mg/kg body weight over a period of seven (7) days. The result obtained showed the detrimental impact of Al2O3– NPs on reproductive health. It suggests that these harmful effects are closely linked to the nanoparticles' chemical composition, size, dosage, and duration of exposure. Specifically, the study highlights that Al2O3– NPs can disrupt the production of sex hormones, leading to adverse effects on sperm quality and potentially resulting in infertility. Given the harmful
effects of aluminum oxide nanoparticles, the use of antioxidants is proposed as a measure to reduce potential risks associated with Al2O3– NP toxicity on the testis and epididymis of male wistar rats.