EFFECTS OF PARKIA BIGLOBOSA LEAF EXTRACT ON SURGICAL WOUND HEALING IN ALBINO RAT

This study was carried out to determine the wound healing potency of Parkia biglobosa ethanol leaf extract on surgical wounds using animal model. Thirty-two (32) healthy female albino rats (Rattus norvegicus), two months old, with an average weight of about 188g were purchased. Normal excision wounded animals in Group 1 (Control) were only given food and water. Group 2 (Standard drug) were given cicatrin powder to treat their wounds. Group 3 were given 10% Parkia biglobosa extract to treat their wounds. Group 4 were given 20% Parkia biglobosa extract to treat their wounds. After seven days, serum blood samples were taken, analyzed for anti-inflammatory. The results of showed that the extracts of P. biglobosa had positive effect on wounded healing. Tumour necrosis factor (TNF-α) of group 1 animals range from 136.0 pg/ml to 110.5 pg/ml, group 2 animals range from 87.0 pg/ml to 117.6 pg/ml, group 3 animals range from 123.45 pg/ml to 117.6 pg/ml, while group 4 animals range from 116.7 pg/ml to 133.6 pg/ml. The Superoxide dismutase (SOD) values of the treated animals were as follows: group 1 animals range from 12.6 U/mg to 18.95 U/mg, group 2 animals range from 17.85 U/mg to 25.15 U/mg, group 3 animals range from 14.2 U/mg to 23.9 U/mg, while group 4 animals range from 14.8 U/mg to 16.1 U/mg. The study recommends that the potential and safety of this plant extract, as well as their possible protective mechanisms, should be determined before administration into humans.