Department
Year of Publication
upload
Publication Type
Abstract
Medicinal plants and the bioactive substances they contain have drawn the interest of various researchers over the past ten years due to their ability to cure different illnesses. Ocimum gratissimum is a member of the Lamiaceae family. It is cultivated in several gardens surrounding village huts in Nigeria under the popular name "scent leaf" for both medicinal and culinary purposes. The aim of this study is to elucidate the effect of ocimum gratissimum on some hematological parameters in male wistar rats. The
effect of methanolic extract of Ocimum gratissimum on some red blood indices of Wister rats was studied using fifteen healthy adult wistar rats with weights ranging between 140-160g. The rats were divided into three groups; control group, low dose group and high dose group. Increasing doses (100mg and 300mgkg-1 body weight) of the extract were administered orally to the other two groups for a period of four weeks. Sample collection was done via cardiac puncture using 5ml syringes. The extract displayed a significant increase (p<0.05) difference in platelet levels when compared with the normal control and a non significant difference (p<0.05) in the other parameters were observed. In conclusion, the extract of gratissimum might be a panacea in the management of anaemic conditions due to its erythropoietic, and/or haematopoietic effects, and beneficial to the blood’s - 5 -
oxygen supporting ability and thrombopoietin, putting into consideration that there were no alteration in the morphology and fragility of the RBCs.
effect of methanolic extract of Ocimum gratissimum on some red blood indices of Wister rats was studied using fifteen healthy adult wistar rats with weights ranging between 140-160g. The rats were divided into three groups; control group, low dose group and high dose group. Increasing doses (100mg and 300mgkg-1 body weight) of the extract were administered orally to the other two groups for a period of four weeks. Sample collection was done via cardiac puncture using 5ml syringes. The extract displayed a significant increase (p<0.05) difference in platelet levels when compared with the normal control and a non significant difference (p<0.05) in the other parameters were observed. In conclusion, the extract of gratissimum might be a panacea in the management of anaemic conditions due to its erythropoietic, and/or haematopoietic effects, and beneficial to the blood’s - 5 -
oxygen supporting ability and thrombopoietin, putting into consideration that there were no alteration in the morphology and fragility of the RBCs.
Supervisor(s)
co-supervisor