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Abstract
Male infertility represents a significant global health concern, often linked to reproductive damage caused by medications. This study investigated the possible therapeutic benefits of aqueous Hibiscus sabdariffa extract in mitigating reproductive toxicity triggered by inhibitor (SSRI), was used to establish a model of drug-induced male infertility by disrupting sperm parameters. Following the induction of damage, the subjects received treatment with the aqueous extract to evaluate its restorative effects on sperm count, motility, morphology. The findings revealed that treatment with 250mg/kg b.wt of Aqueous Hibiscus sabdariffa extract significantly reduced the damage caused by paroxetine, demonstrating notable enhancements in all evaluated sperm parameters and supporting the recovery of reproductive tissue architecture. These results imply that the bioactive compounds present in the aqueous extract of Hibiscus sabdariffa may offer meaningful protective and restorative benefits against drug-induced reproductive issues, yielding a more balanced improvement across the assessed parameters, highlighting it as a promising natural therapeutic alternative for male infertility
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