DEPARTMENT OF MEDICAL BIOCHEMISTRY

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from impaired insulin function. This study investigates the effects of ethanol extract derived from the roots of Tetracera alnifolia on low-density lipoprotein (LDL) cholesterol in streptozotocin-induced diabetic Wistar rats. Diabetes was induced using streptozotocin, after which the animals were treated with varying doses of the plant extract and a standard antidiabetic drug. LDL cholesterol levels were analyzed and compared across experimental groups. The results demonstrated a significant reduction in LDL levels in the extract-treated groups compared to the diabetic control, indicating potential antihyperlipidemic properties. These findings suggest that Tetracera alnifolia may play a beneficial role in modulating lipid profiles under diabetic conditions. Further research is needed to elucidate the underlying mechanisms and evaluate its therapeutic potential.