THE COMPARATIVE TREATMENT EFFECT OF 50mg/kg LISINOPRIL/GLIBERCLAMIDE OR 50mg/kg METHANOL FRACTIONOFSIDAACUTA/CLEOME RUTIDOSPERMA ON HEMATOPOIETIC MODULATIONOFHYPERTENSIVE/DIABETIC WISTAR RATS

Hypertension and diabetes are major global health problems that often occur together, worseningcardiovascular and hematological complications. Standard therapies such as Lisinopril andGlibenclamide are effective but can alter normal blood parameters during prolonged use. Thisstudy compared the effects of Lisinopril/Glibenclamide (50 mg/kg) and the methanol fractionofSida acuta and Cleome rutidosperma (50 mg/kg) on hematopoietic modulation in hypertensiveand diabetic male Wistar rats. Hypertension and diabetes were induced using L-NAMEandStreptozotocin. Rats were divided into seven groups, including normal, untreatedhypertensive/diabetic, and treated groups. Treatments were administered orally for five weeks. Blood samples were analyzed for red and white cell indices, hemoglobin concentration, hematocrit, and platelet parameters. Data were analyzed using ANOVA at p ≤ 0.05. Inductionofhypertension and diabetes caused elevated monocyte and granulocyte counts, indicating systemic 11 inflammation. Both treatments significantly reduced monocyte levels (p < 0.001), but onlytheplant extract reduced granulocyte percentage (p = 0.003), suggesting stronger anti-inflammatoryaction. Lisinopril/Glibenclamide treatment lowered hemoglobin concentration (p = 0.016), whilethe Sida acuta/Cleome rutidosperma extract maintained normal red cell values, showinghematoprotective effects. The drug combination increased platelet count and size, whereas theplant extract preserved normal platelet balance. The methanol extract of Sida acuta andCleomerutidosperma demonstrated comparable—and in some areas superior—hematopoietic andantiinflammatory effects to Lisinopril/Glibenclamide. Its ability to maintain erythroid and immunebalance suggests potential as a natural adjunct or alternative therapy for managing hypertension–diabetes comorbidity. Keywords: Hypertension, diabetes, Sida acuta, Cleome rutidosperma, Lisinopril/Glibenclamide, L-NAME and Streptozotocin