BIOCHEMICAL EVALUATION OF THE KIDNEY IN MALE RATS FOLLOWING SUB-CHRONIC CONSUMPTION OF METHANOL LEAF EXTRACT OF Anthocleista grandiflora

Anthocleista grandiflora has a history of traditional herbal use and has been reported to possess a wide range of therapeutic properties. This current study aimed to explore the effect of chronic administration of a methanol seed extract of Anthocleista grandiflora on the biochemical indicators of renal function in male rats. For this study, twenty male rats were randomly divided into four groups, each consisting of five rats. The extract was administered orally at doses of 200, 400, and 800 mg/kg of body weight for a duration of 28 days. The kidney was harvested and processed histologically and blood samples were taken for biochemical assays. Statistical analysis was conducted using one-way ANOVA with Graph Pad Prism. The findings revealed that there were no significant differences in the sum of the means of all the parameters measured across the groups (P>0.05) when compared with control. Based on the absence of elevated urea and creatinine levels in the blood and the absence of any abnormalities in the histological examination of kidney tissues across all treatment groups, it can be inferred that Anthocleista grandiflora, administered at varying doses over a four-week period, does not appear to have any adverse effects on kidney function.