Benedicta Adesuwa OMOREGBE

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia, which often leads to complications such as increased glycated hemoglobin (HbA1c) levels and imbalances in serum phosphate concentrations. Picralima nitida, a medicinal plant widely used in traditional medicine, has shown potential antidiabetic and biochemical regulatory effects. This study aimed to evaluate the influence of P. nitida on glycated hemoglobin and serum phosphate concentrations in male Wistar rats after a controlled feeding period. A total of [40] male Wistar rats were divided into e perimental groups, including a control group and treatment groups receiving varying doses of P. nitida extract. Blood samples were collected before and after the intervention to assess HbA1c levels and serum phosphate concentrations. The results revealed a significant reduction in HbA1c levels in treated groups compared to the
control, indicating improved glycemic control. Additionally, P. nitida administration didn’t influenced serum phosphate concentrations. These findings highlight the therapeutic potential of Picralima nitida in diabetes management and its possible impact on phosphate metabolism. Further studies are recommended to explore the underlying mechanisms and confirm its clinical applicability

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia, which often leads to complications such as increased glycated hemoglobin (HbA1c) levels and imbalances in serum phosphate concentrations. Picralima nitida, a medicinal plant widely used in traditional medicine, has shown potential antidiabetic and biochemical regulatory effects. This study aimed to evaluate the influence of P. nitida on glycated hemoglobin and serum phosphate concentrations in male Wistar rats after a controlled feeding period. A total of [40] male Wistar rats were divided into experimental groups, including a control group and treatment groups receiving varying doses of P. nitida extract. Blood samples were collected before and after the intervention to assess HbA1c levels and serum phosphate concentrations. The results revealed a significant reduction in HbA1c levels in treated groups compared to the control, indicating improved glycemic control. Additionally, P. nitida administration didn’t influenced serum phosphate concentrations. These findings highlight the therapeutic potential of Picralima nitida in diabetes management and its possible impact on phosphate metabolism. Further studies are recommended to explore the underlying mechanisms and confirm its clinical applicability.