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Abstract
Cadmium is a toxicant that is not just harmful to the gonads but also the liver. In this study, the ameliorating potentials of Cyperus esculentus on cadmium induced toxicity in Liver was evaluated. Thirty-five male albino wistar rats divided into five groups consisting of seven rats each were used for this experiment. All rats were treated orally via gavage for 28 days. The
group 1 served as the control group was administered normal saline while group 2 was treated with Cadmium only (3 mg/kg body weight). Groups 3 and 4 were co-treated with cadmium and Cyperus esculentus extract at doses of 2 and 4 mL/kg body weight respectively. Following this, histopathology were analysed for all the rats. Biochemically, SOD, CAT and
MDA activities were significantly altered (p<0.05) in cadmium treated group. Group 3 rats showed no significant alteration in SOD, CAT and MDA level. However, there was a significant increase in CAT activities in all rats. Histological section through the liver showed inflammation and necrosis in rats in group 2. However, the histology cross section in group 4 and 5 appeared to have recovered from the damages induced by cadmium. These results showed that Cyperus esculentus ameliorated the toxic effects induced by cadmium on the liver by restoring the morphology of the liver in a dose dependent manner.
group 1 served as the control group was administered normal saline while group 2 was treated with Cadmium only (3 mg/kg body weight). Groups 3 and 4 were co-treated with cadmium and Cyperus esculentus extract at doses of 2 and 4 mL/kg body weight respectively. Following this, histopathology were analysed for all the rats. Biochemically, SOD, CAT and
MDA activities were significantly altered (p<0.05) in cadmium treated group. Group 3 rats showed no significant alteration in SOD, CAT and MDA level. However, there was a significant increase in CAT activities in all rats. Histological section through the liver showed inflammation and necrosis in rats in group 2. However, the histology cross section in group 4 and 5 appeared to have recovered from the damages induced by cadmium. These results showed that Cyperus esculentus ameliorated the toxic effects induced by cadmium on the liver by restoring the morphology of the liver in a dose dependent manner.
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