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Abstract
The discovery of serum prostate specific antigen (PSA) and its extensiveuseover the past two decades has dramatically influenced the diagnosis and monitoringof prostate cancer before and after treatment, respectively (Dada et al, 2018). Prostate specific antigen (PSA) is a 28 400Da glycoprotein (Milford et al, 2001)comprising 237 amino acid residues (Lundwall, et al 1991) with five inter-chaindisulphide bonds and approximately 8% carbohydrate in the formof a N-linkedoligosaccharide side chain. In seminal plasma, PSA can be shown toexist infive isoforms, two biologically active and differing in the degreeofglycosylation, and three biologically inactive or `nicked’ forms (Zhanget al, 1999).
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