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This study investigated the pro-fertility effects of pineapple (Ananas comosus) on the reproduction of female Wistar albino rats. Reproductive health represents a fundamental aspect of overall well-being, and the relationship between nutrition and female reproductive function has gained significant attention. The research aimed to evaluate the profertility effects of fresh pineapple juice consumption on reproductive parameters including organ development and hormonal regulation.Thirty Female Wistar albino rats were used as experimental models, with doses of normal control, 5mg/kg Folic acid, 5mg/kg tamoxfene, then 5ml/kg and 20ml/kg of fresh pineapple juice administered over a 21-days treatment period. Results demonstrated significant estrogenic effects with dose-dependent increases in reproductive organ mass,particularly uterine weight, across all treatment groups compared to controls. Hormonal assays revealed notable alterations in reproductive hormone levels, including changes in luteinizing hormone, follicle-stimulating hormone, and estrogen levels, indicating enhanced estrogenic activity and modulation of the hypothalamic-pituitary-ovarian axis. The findings suggest that pineapple extract possesses measurable pro-fertility properties mediated through its complex array of bioactive compounds. The mechanism appears to involve anti-inflammatory effects, antioxidant protection, hormonal modulation that collectively create favorable conditions for reproductive function
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