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Grapes contain bioactive compounds such as polyphenols, resveratrol, flavonoids, and phytoestrogens with antioxidant, anti-inflammatory, and hormone-modulating potentials. Considering the rising prevalence of female infertility and the limitations of conventional therapies, this study explored grapes as a possible natural alternative to enhance reproductive health. This investigation was aimed at evaluating the effect of Vitis vinifera (grape) juice on pregnancy outcome in female rats using experimental animal model. Freshly prepared grape juice was administered orally to gravid albino Wistar rats at doses of 2 mL/kg and 5 mL/kg across the three trimesters of pregnancy. Key parameters assessed included maternal weight gain, serum progesterone levels, implantation sites, uterine horn development, pregnancy outcomes, fetal biometric indices, and blood glucose levels. The results showed significant improvements in maternal weight, progesterone concentration, implantation success, litter size, and fetal development in the grape-treated groups compared to controls. Additionally, low-dose grape juice maintained normoglycemia, while higher doses elevated blood glucose, indicating a dose dependent effect. These findings demonstrate that Vitis vinifera juice positively influences maternal physiology, enhances uterine receptivity, and improves pregnancy outcomes, highlighting its potential role as a nutraceutical for supporting female fertility.
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