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Abstract
This study evaluates the hematoprotective effects of ethanol leaf extract of Acalypha wilkesiana on Wistar rats exposed to 1,2-dimethylhydrazine (DMH), a carcinogen. The experiment involved nine groups of rats with varying treatments: normal control, positive control with DMH and Xeloda (Capecitabine), and several groups receiving different doses of Acalypha wilkesiana extract both before and after DMH exposure. Hematological parameters analyzed included Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC). Results demonstrated significant changes in these parameters among treated groups. Rats treated with Acalypha wilkesiana extract exhibited increased MCV, MCH, and MCHC levels compared to controls, indicating potential hematoprotective properties. Specifically, groups receiving the extract showed improvement in red blood cell indices affected by DMH, suggesting its efficacy in mitigating DMH-induced hematological damage. These findings highlight the potential therapeutic application of Acalypha wilkesiana in managing hematological disorders caused by carcinogenic agents. Further research is necessary to elucidate the mechanisms of action and optimize dosage for clinical use. Overall, this research opens promising avenues for utilizing natural remedies to enhance patient well- being and combat hematological abnormalities
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