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Abstract
Glyphosate is a non-selective systemic herbicide and the most often used pesticide globally. This study examined the effects of antioxidant levels in the liver and kidney of Wistar rats fed maize- based diets formulated from grains obtained from glyphosate-exposed soils. The rats were 15 in total and were grouped into A (commercial feed only), C (maize grown on glyphosate controlled weed field above the recommended dose), F (maize grown on glyphosate controlled weed field following the recommended dose + raw glyphosate (2ml), G (maize grown on glyphosate controlled weed field following the recommended dose), and H (feed produced from maize grown by local farmers), and were maintained under standard conditions for the duration of 28 days. Antioxidant parameters such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and malondialdehyde (MDA) were analyzed. The following results showed reduced activities of antioxidant enzymes in the glyphosate-fed groups compared to group A, indicating the presence of oxidative stress and lipid peroxidation. The various activities suggest that glyphosate residues in feed may disrupt cellular redox balance, compromise organ function, and increase susceptibility to oxidative damage. Overall, the study discussed the potential health risks associated with the consumption of crops cultivated on glyphosate exposed soils and the need for continuous monitoring of herbicide residues in animal feed and food chains.
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